Interface
to insight

Email: cliu232@jh.edu

LinkdeIn: www.linkedin.com/in/chang-liu-holly

Chang (Holly) Liu

My research focuses on biosensing interfaces and translational sensor design, developing systems that combine engineering precision with clinical relevance. I became deeply interested in how sensor technology can bridge the gap between laboratory innovation and patient care, particularly through projects that bring biosensing systems into real clinical environments. Recently, I have worked on an in-ear sensor platform deployed for brain injury patients, which has led to a manuscript under review at ACS Applied Materials & Interfaces. My long-term goal is to advance sensor technologies that move beyond prototypes and become trusted, decision-shaping tools in everyday healthcare.

Master Thesis at JHU: NeuroTex: Functionalized Hybrid Polymer-Metal Textile for Soft, Robust, and Dry Auricular Neural Interfaces.

Advisor: Prof. Nitish V. Thakor

Collaborators: Prof. Howard E. Katz, Dr. Gerwin Dijk, Dr. Sung-Min Cho

Undergrad Thesis at CUHK(SZ): Electrochemical Biosensor For the Detection of IL-6 Towards Inflammation Diagnosis

Advisor: Prof. Guozhen Liu

Full CV

Our
Projects

Outcomes

Liu, C., Ascani Orsini, A., Perkins, P., Dijk, G., Katz, H., Xu, h., Wang, M., Cho, S.M., and Thakor, N. “NeuroTex: Functionalized Hybrid Polymer-Metal Textile for Soft, Robust, and Dry Auricular Neural Interfaces.” ACS Appl. Mater. Interfaces 8 April 2026; 18 (13): 19720–19735. https://doi.org/10.1021/acsami.5c20429

Ascani Orsini, A., Liu, C., Shen, B., Cao, M., Xu, H., Ananthakumar, T., Cho, S. M., and Thakor, N. “Auricular Electrophysiology Demonstrates Enhanced Stability Under Vehicle Vibration and Acceleration.” Military Medicine, Volume 191, Issue Supplement_1, July/August 2026, Pages 145–154, https://doi.org/10.1093/milmed/usag045

Ascani Orsini, A., Guo, D., Xu, H., Lai, Y., Liu, C., Wang, M. "Mechanically Isolating and Self-Monitoring Low-Cost Phononic Connectors for Amorphous Wearable Bioelectronics." IEEE Sensors Letters, vol. 10, no. 10, pp. 6500304-6500304, Oct. 2026, Art no. 6500304, doi: 10.1109/LSENS.2026.3734690.

Journal Articles

Peer-Reviewed Conference Papers

Liu, C.*, Ascani Orsini, A.*, Perkins, P., Cho, S. M., and Thakor, N. “Listening to the Brain: A Computational Method for Modeling Ear Canal Spatial Sensitivity to Distinct Brain Sources.” 2025 12th International IEEE/EMBS Conference on Neural Engineering (NER), San Diego, CA, USA, 2025, pp. 1-6, doi: 10.1109/NER61569.2025.11589018.

Liu, C. “Application of ECoG and Electrode in BCI.” Theoretical and Natural Science, 3(1):410–416, April 2023. DOI: 10.54254/2753-8818/3/20220290

Conference Presentations

Liu, C., Perkins, P., Ascani Orsini, A., Xu, H., Cho, S.M., and Thakor, N. “NeuroTex: Functionalized Hybrid Polymer-Metal Textile for Soft, Robust, and Dry Auricular Neural Interfaces.” Poster presented at ACCM Research Day - Baltimore, December, 2025.

Liu, C.*, Ascani Orsini, A.*, Perkins, P., Cho, S. M., and Thakor, N. “Listening to the Brain: A Computational Method for Modeling Ear Canal Spatial Sensitivity to Distinct Brain Sources.” Poster selected for Spotlight Session and presneted at IEEE EMBS NER 2025 - San Diego, November 2025.

Liu, C., Perkins, P., Ascani Orsini, A., Xu, H., Cho, S.M., and Thakor, N. “PEDOT:PSS Enhanced Dry E-textile Electrode for Reliable In-Ear EEG Monitoring.” Poster presented at 248th ECS Meeting - Chicago, October 2025.

Liu, C., Perkins, P., Ascani Orsini, A., and Thakor, N. “NEUROTEX: PEDOT:PSS-Enhanced Silver/Nylon E-Textile Electrodes for High-Performance Wearable Bio-Signal Monitoring.” Poster presented at NANS Neural Interfaces - Arlington, June 2025.

Eashwer, A., Ascani Orsini, A. A., Rathi, P., Khan, S., Liu, C., Perkins, P., and Thakor, N. “TISsue-Tune: Precision Multi-Channel Stimulator for Temporal Interference Neuromodulation.” Poster presented at NANS Neural Interfaces - Arlington, June 2025

Patents

Liu, C. (2025). On-body Instant Customizable Ear-electrode. JHU Invention Disclosure, Invention ID: D19152. Filed September 22, 2025. Provisional Patent.